Assessing the clinical relevance of drug-drug interactions (DDI) with darolutamide (DARO)
نویسندگان
چکیده
منابع مشابه
DDI-CPI, a server that predicts drug–drug interactions through implementing the chemical–protein interactome
Drug-drug interactions (DDIs) may cause serious side-effects that draw great attention from both academia and industry. Since some DDIs are mediated by unexpected drug-human protein interactions, it is reasonable to analyze the chemical-protein interactome (CPI) profiles of the drugs to predict their DDIs. Here we introduce the DDI-CPI server, which can make real-time DDI predictions based only...
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Most drugs are taken orally. For those intended to act systemically, a significant fraction of the dose can be eliminated during its first passage through a sequence of organs before entry into the general circulation. For some drugs, the degree of first-pass elimination can be large enough such that oral bioavailability is significantly reduced, with the consequent potential for a reduced clin...
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This work describes the participation of the WBI-DDI team on the SemEval 2013 – Task 9.2 DDI extraction challenge. The task consisted of extracting interactions between pairs of drugs from two collections of documents (DrugBank and MEDLINE) and their classification into four subtypes: advise, effect, mechanism, and int. We developed a two-step approach in which pairs are initially extracted usi...
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ژورنال
عنوان ژورنال: Annals of Oncology
سال: 2019
ISSN: 0923-7534
DOI: 10.1093/annonc/mdz248.047